Fig. 8. Models for the roles of G/GPR-1/2 and LET-99 in transmitting polarized signals during nuclear rotation in P lineage and EMS cells. LIN-5 is required for cortical localization of GPR-1/2 in P cells and EMS cells, and the enrichment of LIN-5 and GPR-1/2 at the EMS/P₂ boundary is MES-1 dependent (Srinivasan et al., 2003). LET-99 asymmetry (blue band) and its downstream effects are shown in blue. G/GPR-1/2 (red outline) and its downstream effects are shown in red. Notice that the G/GPR-1/2 levels at the EMS/P₂ boundary are particularly high (thick red line), where LET-99 is absent. Orange arrows indicate the types of nuclear rotation (free versus directed). See text for details.

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