Fig. 8. Summary diagram of the present study and a model for intracortical migration of GABAergic neurons. (A) The migratory behavior of GABAergic neurons in E13.5 neocortex. Dorsomedially directed tangential migration was most prominent in the lower intermediate zone (IZ), but some of the neurons deflected towards the marginal zone (MZ). Neurons in the MZ tangentially migrated in many directions (4), although many of them are stationary (blue spheres). (B) The modes of migration of GABAergic neurons observed in the coronal plane of E15.5 neocortex. Tangentially migrating IZ/SVZ neurons continue to migrate towards the hippocampus (1), whereas those deflected towards the pial surface migrate radially (2) or with some angle to the radial axis (3), towards the MZ. In the MZ, a part of these neurons may migrate on the tangential plane in many directions and spread into the whole cortical areas (see neurons labeled by 4). A part of these neurons may descend from the MZ to be integrated into CP (5). Intracortical migration occurs independent of Tag1⁺ axons (yellow). Red spheres represent motile cells.

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