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First published online November 3, 2003

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Ebf genes find their place in neurogenesis

Neurogenesis requires the coordination of numerous events, including the commitment of cells to specific fates, cell-cycle exit, migration and differentiation. In the mouse and frog, helix-loop-helix transcription factors of the Ebf family have been implicated in neurogenesis but their precise roles are unknown. On p. 6013, Garcia-Dominguez et al. describe a functional analysis of the chick orthologs of mouse Ebf1 and Ebf3. Electroporation of a dominant-negative form of Ebf1 into the chick neural tube shows that Ebf is required for neuronal differentiation and migration, but not for cell-cycle exit, indicating that Ebf genes couple cell-cycle exit with neuronal differentiation and migration. Additional experiments indicate that Ebf genes are also involved in the stabilisation of the committed state, and in neuronal subtype specification. The researchers conclude that Ebf genes lie downstream of proneural gene expression and cell-cycle exit, but upstream of neuronal differentiation and migration in central nervous system neurogenesis in higher vertebrates.

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Related articles in Development:

Ebf gene function is required for coupling neuronal differentiation and cell cycle exit

Mario Garcia-Dominguez, Christophe Poquet, Sonia Garel, and Patrick Charnay
Development 2003 130: 6013-6025. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?