Fig. 6. Defects in ventricular morphology emerge by 48 hpf in wea mutants. (A-F) Lateral views, anterior to the left, of whole-mount immunofluorescence with the anti-tropomyosin antibody CH1 (FITC). Ventricle (V) and atrium (A) are indicated. (A-C) At 36 hpf, the wild-type ventricle (A) and the wea mutant ventricle (B,C) have similar morphology. The wea mutant atrium is slightly dilated at this stage. (D-F) At 48 hpf, the wea mutant ventricle (E,F) is noticeably smaller than the wild-type ventricle (D). The morphology of the wea mutant ventricle varies between individuals (E,F), as does the degree of dilation of the wea mutant atrium. Distortion of cardiac looping is also apparent in wea mutants at this stage.

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