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First published online November 17, 2003

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Cracking open the Drosophila eggshell

Late in Drosophila oogenesis, a flat epithelium consisting of somatically derived follicle cells is remodelled into two tubes that secrete proteins that form the long tubular dorsal appendages (DAs), the specialised respiratory structures of the eggshell. On p. 6273, Tran and Berg describe how bullwinkle (bwk), a germline-expressed transcription factor, and shark, a newly identified enhancer of bwk expressed in somatic squamous stretch cells, regulate DA morphogenesis. shark, which encodes a non-receptor tyrosine kinase, was identified as an enhancer of bwk in a genetic-modifier screen. The researchers then used loss- and gain-of-function strategies to show that shark expression in the stretch cells requires bwk activity and that shark is required in the follicle cells for migration of the DA cells. The researchers conclude that shark plays an important downstream role in the bwk-signalling pathway and suggest that this pathway may be conserved in vertebrates.

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Related articles in Development:

bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis

David H. Tran and Celeste A. Berg
Development 2003 130: 6273-6282. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?