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Fig. 1. FGF8 begins to be expressed in the mouse mid/hindbrain region prior to
Fgf18 and can induce Fgf18 expression in mouse midbrain
explants. (A-C) Fgf8 is first expressed (arrowheads) in the
mid/hindbrain region at the four-somite stage (C). (D-F) Fgf18 is
first expressed in the mid/hindbrain region at the five-somite stage
(arrowhead in E) and becomes restricted to a narrow transverse band straddling
the isthmus by E9.5 (arrowhead in F; asterisk in D indicates the presumptive
mid/hindbrain junction region). (G,H) Fgf18 is induced by
FGF8b-soaked beads (arrowhead in H) by 48 hours, but not by BSA-soaked beads
(G). Inset in H shows that Fgf18 is induced by FGF8b by 16 hours.
(I,J) Fgf17 expression is first detectable in the mid/hindbrain
region at the six-somite stage and at E9.5 it is in a broad domain on both
sides of the mid/hindbrain junction (arrowheads). (K,L) Fgf17 is not
induced after 48 hours by either the BSA-soaked or FGF8-soaked beads in
rostral midbrain explants. Arrowhead in L indicates the endogenous
Fgf17 expression sustained in the explant. Broken lines in F and J
indicate the tissues used for the explant assays.
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