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Fig. 7. Activated FGFR1 and FGFR2 produce over-proliferation of the midbrain. (A) Dorsal view of an E10.5 chicken brain electroporated with 1 µg/µl pMiw-Fgfr1K656E, the midbrain on the transfected side is larger than the one on the control side. (B) Dorsal view of an E7.5 chicken brain electroporated with 3 µg/µl pMiw-Fgfr1N546K, the midbrain on the transfected side is larger than the one on the control side. (C) Dorsal view of an E7.5 chicken brain electroporated with 1 µg/µl pMiw-Fgfr2C342Y, the midbrain on the transfected side is larger than the one on the control side. In all panels, the right sides are the experimental sides and the left sides serve as controls. Broken outline indicates the expanded midbrain.





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