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Fig. 1. Expression of Bmp and BMP antagonist genes during mouse genital tubercle
(GT) development. (Top) SEM picture of an embryonic GT at 12.5 dpc (green line
indicates urethral plate). The arrowhead indicates the distal urethral
epithelium (DUE; which is covered with an epithelial layer). (A) Bmp2
expression was localized to the urethral epithelium (black arrowhead) and
proximolateral mesenchyme (white arrows) of the GT at 12.5 dpc. (B) By 12.5
dpc, the expression of Bmp4 was detected in the mesenchyme along the
urethral plate and also around the DUE (white arrows). (C) Bmp7 was
expressed in the DUE (white arrow) and in the urethral epithelium with its
expression level moderately higher in the distal and lower in the proximal
regions. (D) Nog was expressed in the mesenchyme around the DUE
(white arrows). Its expression was also localized in the proximal mesenchyme
around the urethral plate (white arrowhead). (E) Bambi was expressed
in the mesenchyme with its expression level moderately higher in the distal
and lower in proximal regions. All figures are ventral views. Scale bar: 250
µm.
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