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Fig. 3. Comparison of gene expression profiles of ß-catenin and
Cripto or Wnt3 mutant embryos. Fold changes of expression of
selected genes in mutants compared with wild-type embryos, and the tissue
specific expression of these genes in wild-type embryos are shown. Genes were
selected from all genes that are deregulated in the respective mutants (see
http://www.mdcberlin.de/~zelldiff).
(A) Genes commonly deregulated in both ß-catenin and Cripto
mutants at E6.0. Upper panel, commonly downregulated genes with putative
signalling or developmental functions; lower panel, commonly upregulated genes
of which ESTs have been preferentially isolated from neural tissues. (B) Genes
commonly downregulated in both ß-catenin and Wnt3 mutants at
E6.5. Upper panel, genes downregulated specifically at E6.5 (late genes);
lower panel, genes deregulated at both E6.5 and E6.0 (early genes); in
brackets, fold change at E6.0. nd, not determined. Red, high relative
expression; blue, low relative expression; bright area, genes with consistent
measurements; dark area, genes with variable or low measurements in certain
tissues.
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