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Fig. 4. Expression of Fgf3 and Fgf10 during inner ear formation.
(A-C) Expression of Fgf3 was detected at the stages indicated by
whole-mount in situ hybridization. The position of the prospective rhombomeres
and rhombomeres are indicated. The arrow in B indicates the level of the
transversal section shown in C, where expression in the hindbrain and otic
placode can be observed. (D-N) Expression of Fgf10 was detected by
whole-mount RNA in situ hybridisation at the stages of development indicated.
(D-F) Expression of Fgf10 is observed in the anterior mesenchyme (m).
The arrow in D indicates the level of the transversal section shown in E. A
transverse section at this level in a four-somite stage embryo shows that
Fgf10 expression is localized to ventral anterior mesenchyme (F).
(G-N) Expression of Fgf10 in the hindbrain. To facilitate the
localisation of Fgf10 expression relative to the position of
rhombomeres 5 and 6, a probe for the Mafb gene was used in G-K. (L-N)
Transverse sections at the levels indicated by arrows in H,I,K, respectively,
show expression of Fgf10 restricted to the ventral part of the
hindbrain. The broken line in I indicates the position the otic placode. In K
and N, Fgf10 expression is also detected in the anterior part of the
otic cup. Scale bars: in A, 200 µm for A; in B, 200 µm for B; in D, 50
µm for D; in G, 200 µm for G; in H, 200 µm for H; in I, 200 µm for
I; in J, 200 µm for J; in K, 200 µm for K.
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