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First published online December 1, 2003

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Sugary Notch activation

Signalling through the transmembrane receptor Notch is central to many cell-fate decisions in metazoan development. Activation of Notch by its ligands - Delta and Serrate in Drosophila - is regulated by O-fucosylation within the epidermal growth factor (EGF) repeats of Notch. To find out which of the many potential O-fucosylation sites are important for Notch activation, Lei et al. assayed the effects of eliminating several putative Notch O-fucose attachment sites on Notch activation in Drosophila wing cells (see p. 6411). Out of the four conserved sites tested, only elimination of the O-fucosylation site in Notch EGF12 prevented the normal inhibition of Serrate-to-Notch signalling by Fringe, a glycosyltransferase that elongates O-fucose chains. These and other results indicate that inhibition of Notch-Serrate binding by O-fucosylation of Notch EGF12 is needed in certain contexts to allow efficient regulation of Notch signalling.

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Related articles in Development:

An O-fucose site in the ligand binding domain inhibits Notch activation

Liang Lei, Aiguo Xu, Vladislav M. Panin, and Kenneth D. Irvine
Development 2003 130: 6411-6421. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?