QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 1, 2003

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

A change of mind

In zebrafish acerebellar (ace) embryos, a point mutation in fgf8 prevents the formation of the isthmic constriction, which contains the midbrain-hindbrain boundary organiser, leading to the loss of cerebellar development and the formation of an enlarged tectum. On p. 6611, Jászai et al. report that these morphological features are the result of an alteration of cell fate in the fgf8 mutant brains. By comparing gene expression patterns in wild-type zebrafish and ace mutants, the researchers demonstrate that a caudal-to-rostral switch in cell fate underlies the tectal expansion in the mutants and that this transformation is not due to alterations in cell proliferation or cell death. They also report that implantation of Fgf8-coated beads into the prospective midbrain-hindbrain boundary rescues the ace mutant phenotype, indicating that the absence of the inductive organiser signal Fgf8 is responsible for the cell-fate alterations seen in the ace mutant.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity

József Jászai, Frank Reifers, Alexander Picker, Tobias Langenberg, and Michael Brand
Development 2003 130: 6611-6623. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?