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Fig. 5. sma-9 functions in early stages to regulate body size. (A) Growth
curve of sma-9 (cross), sma-4 (triangle),
dbl-1(square) and N2 (diamond). In L1 stage larvae (12 hours), all
animals are the same length. In L1 through L3 stages (48 hours), sma-9,
sma-4 and dbl-1 show reduced a growth rate compared with N2.
After L3, sma-9 mutants grow rapidly, whereas dbl-1 and
sma-4 mutants continue to display a reduced growth rate. Data for N2
and dbl-1 is from Savage-Dunn et al.
(Savage-Dunn et al., 2000).
(B) At L3 stage, sma-9 worm length, pharynx length and seam cell
length is indistinguishable from that of dbl-1 and sma-4.
Data for N2 and dbl-1 is from Wang et al.
(Wang et al., 2002). (C) Model
of sma-9 function in the DBL-1 pathway. In body size development,
sma-9 functions in early larval stages and may be replaced by other
transcriptional cofactors in late larval stages. In male tail development,
sma-9 prevents fusions in rays 8-9 specifically, but regulates
cat-2 activity, the rate-limiting step in dopamine expression, in all
rays. Other cofactors may be involved in ray 4-5 and 6-7 fusions. For spicule
development, both sma-9 and other cofactors are probably
required.
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