|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 5. Retinoic acid regulation of endothelial cell cycle progression. (A)
Endothelial cells were cultured (10,000/well) for 72 hours in control
conditions or with 0.5 µM RA, 0.5 µM MA or 0.5 µM TTNPB. RA
significantly suppressed the increase in endothelial cell number seen over
time in culture in control cells, in a process specifically mediated via RAR
receptors (A). (B) Fixed control and RA-treated endothelial cells were stained
with propidium iodide and subjected to FACS. RA significantly decreased the
proportion of endothelial cells in S phase, and increased the proportion of
cells in G1 phase, but did not induce apoptosis.
|
