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Fig. 6. Mechanism by retinoic acid regulates endothelial cell cycle progression.
Total protein was isolated from control or RA-treated endothelial cells,
immunoprecipitated with antibodies against Cdk4, p21 or p27, and subjected to
western analyses. Complex formation between cyclin D1 or D2 and Cdk4 was
significantly reduced in RA-treated endothelial cells, whereas complex
formation between RA-induced p21 and Cdk4, as well as cyclins D1 and D2, was
greatly enhanced (A). There were lower levels of phosphorylated Rb protein in
RA-treated endothelial cells, compared with controls (B).
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