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Fig. 1. Grossly visible phenotypes of hlh-14 mutants. (A) The tail of a wild-type C. elegans larva. (B) An hlh-14(gm34) larva. hlh-14 mutant worms can have disorganized, lumpy tails (arrow) and, less often, lumps at other positions along the AP axis. The cellular bases for these morphological defects are unclear. (C,D) hlh-14(RNAi) larvae. hlh-14(RNAi) larvae can display a range of morphological defects. (C) A severely affected hlh-14(RNAi) animal with a large posterior bulge (arrow). (D) An animal mildly affected by hlh-14(RNAi) treatment, showing only a small bump in the tail (arrow). Some hlh-14(RNAi) animals have a normal body structure, but still display neuronal phenotypes, indicating that these two phenotypes can be uncoupled.





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