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Fig. 3. Loss of RARE function affects Cdx1 expression in vivo. Whole-mount
in situ hybridization analysis of Cdx1 expression in wild type
(A,C,E) and RARE mutants (B,D,F). All stages to be compared were processed and
stained in parallel. (A,B) Analysis of early E7.0 to late head folds stages
demonstrates onset of Cdx1 expression at late primitive streak stages (E7.5)
in both wild-type (A) and RARE mutant embryos (B). Dark field micrographs are
shown for ease of stage comparison. (C,D) Wild-type (C) and RARE mutant (D)
embryos ranging from 1 (left) to 7 (right) somites. Note the diminution of
expression in mutant embryos relative to stage matched controls. (E,F)
Wild-type (E) and RARE mutant (F) embryos ranging from 7 (left) to 13 or 14
(right) somites. Note the near loss of expression in the mutants relative to
stage matched controls.
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