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Fig. 4. Cdx1 is induced by RA in RARE-null mutants. In situ hybridization
analysis of Cdx1 expression of wild-type (A,B,E,F,I,J,M,N) or
Rare-/- (C,D,G,H,K,L,O,P) embryos following treatment with
vehicle (A,C,E,G,I,K,M,O) or RA (B,D,F,H,J,L,N,P) at E7 (A-D), E7.5 (E-H),
E8.0 (I-L) or E8.5 (M-P). All embryos were recovered 4 hours after in utero
treatment with RA and equivalent stage matched samples processed in parallel
for analysis. Note that Cdx1 was induced by RA at gastrulation
stages, with induction seen in both wild-type (A versus B) and RARE mutants (C
versus D). Induction also occurred at all later stages irrespective of
genotype.
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