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Fig. 6. Skeletal defects in RARE and RARE-Cdx1 compound mutants. Representative skeletal preparations from neonatal offspring; genotypes are indicated in each panel. Asterisk indicates ectopic anterior arch of the atlas (AAA) indicative of C2 to C1 transformation (C-F). Brackets (E,F) indicate narrower then normal neural arches (NA) on C1, indicative of a transformation to an exoccipital-like structure, while the arrowhead and broad arrow (E,F) indicate a broader C2 neural arch, suggestive of C2 to C1 and C3 to C2 transformations, respectively. TA (E,F) indicates the anterior tubercles, normally found ventral to C6, that have been shifted posteriorly to the seventh cervical element. Thin arrow (E,F) indicates posterior extension of the basioccipital.





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