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Fig. 7. Fgf8-bead implantation restores the molecular and anatomical identity of
the MHB territory. All views are rostral to the left, and are dorsal aspects.
(A) The Epha3-AP fusion protein reveals the distribution of ephrin ligands
(blue) in the mesencephalic tectum. (B) The fusion protein fails to detect the
typical ephrin gradient expression in the mutant tecta. (C) After implanting
Fgf8-coated beads into the wild-type diencephalon, a second, mirror gradient
of ephrin A proteins can be detected. Arrowhead indicates the implanted beads;
arrows indicate the second, ectopic ephrin A domain. (D) Unilateral
implantation of the Fgf8-coated beads into ace embryos is able to
restore the graded ephrin A expression on the operated side.
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