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Fig. 8. Organization of the MHB region in the presence (wt) and absence
(ace) of functional Fgf8 signaling. In the presence of the functional
organizer signal Fgf8 (red block) the MHB region is correctly patterned, and
the mid- and hindbrain regions are separated by the isthmic constriction
(dotted line). The mesencephalic tectum (Mes) is polarized, as revealed by the
graded expression of various markers (gradient green). In the ace
mutant, where functional Fgf8 is absent, the isthmic indentation fails to
form, the tectum expands caudally at the expense of the metencephalon (Met),
and it loses its polarized character, showing gene expression profiles
characteristic of the anterior tectum in wild-type embryos (gray block).
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