Fig. 6. Aortic arch defects in E18.5 embryos. (A) Corrosion cast of PDGFR^fl/fl; Wnt1Cre^-. (B-D) PDGFR^fl/fl; Wnt1Cre⁺ embryos. (A) Architecture of normal aortic arch where the ascending aorta has three branches. The brachiocephalic artery bifurcates into the right subclavian (a) and right common carotid (b) arteries. The next branches are the left common carotid (c) and left subclavian (d) arteries. The ductus arteriosus (da) branches off the descending aorta (dAo) with the two pulmonary arteries (pa) branching from the pulmonary trunk. (B) Persistent truncus arteriosus (PTA) and a retro-esophageal subclavian artery. Arrow indicates to the ectopic origins of the right subclavian artery. Inset in B is a higher magnification and is taken from a slightly different angle, illustrating that the pulmonary arteries are emerging from the persisting truncus arteriosus. (C) Double outlet right ventricle and retro-esophageal right subclavian artery. The left common carotid artery was broken during manipulation. (D) Right subclavian artery originates from the proximal pulmonary trunk, where it bifurcates into the pulmonary arteries. The left pulmonary artery was broken during manipulation.

Return to article