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Fig. 9. NCC fate mapping. E9.5 embryos carrying the ROSA26 Cre reporter were stained for ß-galactosidase activity. (A,B) Wholemounts. (A, left) PDGFR{alpha}fl/+;Wnt1Cre+. (A, right) PDGFR{alpha}fl/fl;Wnt1Cre+. (B) Higher magnification of the migrating NCCs in the PDGFR{alpha}fl/fl;Wnt1Cre+ embryo. Arrows indicate NCCs that have migrated to form part of the peripheral nervous system. (C,D) Transverse sections through conotruncal area of (C) PDGFR{alpha}fl/+;Wnt1Cre+ and (D) PDGFR{alpha}fl/fl;Wnt1Cre+ embryos. Arrows indicate NCCs migrating into the truncus arteriosus. Abbreviations: s, aortic sac; ta, truncus arteriosus.





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