Fig. 2. The size and lamination defects of Chx10-null retinas are markedly rescued in Chx10, Kip1 double null retinas. The different eye sizes of adult wild type (A), Chx10-null (B), Chx10, Kip1 double null (C) and Kip1-null mice (D) are readily observable. (E-H) Retinas from postnatal day 19 for each genotype, photographed after dissection and removal of the lens. The pigmented tissue at the margins of the Chx10-null and (to a lesser extent) double null retinas was adherent to the retinal tissue. (I-L) Radial cross-sections through the retinas pictured in A-D, showing that the Chx10, Kip1 double null retina has normal lamination, in contrast to the Chx10-null retina. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Scale bar: 1 mm for E-H; 150 µm for I-L.

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