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Fig. 4. Bipolar cells are absent in the otherwise morphologically normal Chx10, Kip1 double null retina. In a cross-section from P19 wild-type retina (A), both bipolar cell bodies (arrows) and the synaptic termini (arrowheads) that they make with ganglion cells are clearly visible with PKC-{alpha} staining. In the double null (B), only amacrine (INL) and displaced amacrine cell (GCL) immunoreactivity is visible. ONL, outer nuclear layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 20 µm.





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