Fig. 7. LIF transiently delays somatic growth of LGN, visual cortex and SGS neurons. White bars represent contralateral and black bars ipsilateral values. The small insets indicate the percentage of median shift in the individual animals analyzed. (A) After P12-20 LIF infusions ipsilateral LGN neurons were consistenly shifted to smaller sizes (MWU-test, ipsi versus contra, P<0.0001). (B) However, during a survival period until P45, ipsi- and contralateral LGN neurons had aquired the same adult size variation, and like NT-4/5 (Fig. 2A,C) the P45 peaks occurred at larger sizes than at P20. (C) Furthermore, LIF severely affects growth of primary visual cortex layer IV (diamonds) and layer VI neurons (triangles; MWU-test ipsi versus contra P<0.0001 for both populations). (D) LIF affects SGS neurons, which were consistently smaller on the infused hemisphere. This was true for the total SGS neurons (diamonds) and for the tectothalamic CB neurons (circles; significant difference to cytochrome C, one way ANOVA P<<0.05, Tukey's post hoc test). The growth delay is transient, because after survival to P45 some size distribution has recovered (total SGS neurons at P45 represented by triangles up, and CB neurons at P45 by triangles down).

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