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Fig. 5. UNC-115 acts downstream of Rac signaling in CAN and PDE axon pathfinding. The genetic relationships between the three racs, unc-73 and unc-115 are shown. Arrows indicate that the genes act in the same pathway. Three rac genes ced-10, mig-2 and rac-2/3, define three parallel pathways with overlapping function. unc-73 acts in all three pathways, and unc-115 acts downstream of rac-2 and possibly ced-10. unc-73 might have rac-independent roles in axon pathfinding possibly mediated by the rho-1 gene that encodes the single C. elegans Rho GTPase. GEF, GTP exchange factor; abp, actin-binding protein.





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