Fig. 7. A model for DIF-induced nuclear accumulation of Dd-STATc. The Dd-STATc protein is proposed to be predominantly cytosolic in the absence of DIF, because the NESs in the EXP region predominate over the NLSs present within the IMP region (illustrated by the number of crosses). The model proposes a conformational change when Dd-STATc monomers dimerise, in reponse to DIF treatment, that masks the activity of EXP. The increased relative activity of the nuclear import signal(s) in the IMP regions then causes Dd-STATc to accumulate within the nucleus.

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