Fig. 1. Morphological features of embryos injected with szl RNA or with the antisense morpholino oligo. (A) Sibling embryos derived from a single frog were injected with the morpholino oligo MOSZL in both blastomeres at the two-cell stage, or with Szl RNA in the ventral marginal zone at the four-cell stage. Representative stage 33/34 embryos are sorted along a theoretical gradient of Szl protein levels. (B) Sibling embryos were injected with 20 ng MOSZL in both blastomeres at the two-cell stage, or with 40 pg wSzl RNA in the marginal zone at the four-cell stage. Development of a small group of injected and uninjected embryos was recorded by video time lapse between neurula and tailbud stages. For clarity, a single representative individual is shown at each time point (in h:m:s below each panel).

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