spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 4. Overexpression of Ihh in the Wnt5a mutant. Skeletal preparations and sections (bottom row) of the forelimb of 18.5 dpc mouse embryos are shown. Ihh was overexpressed in the chondrocytes in the Col2a1-Gal4;UAS-Ihh mice. Joint formation was suppressed and ectopic ossification was observed in the elbow and knee regions (arrows). In the Col2a1-Gal4;UAS-Ihh; Wnt5a-/- mouse, the long bones were slightly longer than the Wnt5a-/- mutant (arrowheads), but much shorter than the Col2a1-Gal4;UAS-Ihh mutant. Suppression of joint formation and ectopic ossification in Col2a1-Gal4;UAS-Ihh; Wnt5a-/- embryos (arrows) resembled the Col2a1-Gal4;UAS-Ihh mutant, but in a much smaller region. H, humerus; R, radius; U, ulna; Fe, femur; T, tibia; Fi, fibula.





Right arrow Return to article