Fig. 7. Proposed mechanism of the role of Dax1 in sex differentiation. Expression of Dax1 (red) in relation to dividing cells (BrdU, green) at 12.5 dpc. Broken line reflects the coelomic surface. TC, testis cords. Arrow indicates Dax1-positive cells below the coelomic surface. Dax1 is expressed in both Sertoli cells and somatic cells below the coelomic epithelium. L, Leydig cells; S, Sertoli cell. Schematic illustrates that Dax1 appears to have a role in regulation of PTM cell development by either determining the fate of cells at the coelomic epithelium or by regulating the proliferation of PTM cells around the testis cord.

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