Fig. 6. Maelstrom is implicated in miRNA/RNAi pathways. Dicer in a wild-type ovariole (A, enlarged in A') is ubiquitously expressed and primarily cytoplasmic in both germline and somatic cells. In maelstrom ovarioles (B, enlarged in B'), Dicer is ectopically localized to discrete punctae, which are frequently perinuclear in stages 3-9 nurse cells. A wild-type ovariole (C, enlarged in C') labeled for Vasa (red channel) and AGO2 (green channel). AGO2 appears as small, irregular particles distributed randomly in the cytoplasm of germ cells. (E, enlarged in E') Wild-type AGO2 channel alone. In maelstrom ovarioles (D, enlarged in D'), AGO2 (green channel) aggregates in perinuclear halos that overlap Vasa (red channel). (F, enlarged in F') maelstrom AGO2 channel alone. AGO1 shows no discernable subcellular localization in either wild-type (G, enlarged in G') or maelstrom ovarioles (H, enlarged in H').

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