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Fig. 1. The mediolateral intercalation behavior (MIB) hypothesis. (A) Early protrusive activity is random. (B) The cells take on a bipolar shape as their protrusions are restricted to the ML axis. Protrusive activity is not present at the notochord/somite boundaries (to the sides). (C) The field narrows and elongates (converges and extends) as the cells exert traction upon one another and pull together. Adapted, with permission, from Shih and Keller (Shih and Keller, 1992a).





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