Fig. 7. RNCAM isoform-dependent variations in the number of laterally and medially located semi-innervated P2 glomeruli. Number of semi-innervated P2 glomeruli was quantified on serial sections of olfactory bulb stained for ß-galactosidase activity. Graphs represent total number of semi-innervated P2 glomeruli located in the medial (M) and lateral (L) hemisphere of the olfactory bulb in control mice (cont) (n=36), TmRNCAM transgenic mice (Tm) (n=26), GpiRNCAM transgenic mice (Gpi) (n=42) and TmRNCAM/GpiRNCAM (Gpi/Tm) double transgenic mice (n=16). Results are mean±s.e.m. ^***P<0.0001, ^**P<0.005, ^*P<0.05; Student's t-test. The fractions of semi-innervated P2 glomeruli located proximal (37%) and caudal (63%) to the main lateral P2 glomerulus in GpiRNCAM transgenic mice were calculated from analyses (shown in Fig. 6) that were carried out to determine both rostrocaudal and mediolateral distances. The data were obtained from progeny of two transgenic founder lines transgenic for each RNCAM isoform.

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