Fig. 8. Maintained Krox20 expression in the migrating neural crest requires Sox10. (A,B) The expression of Sox10 was analysed by in situ hybridisation in mouse embryos at 8.5 dpc. (A) Whole mount of a wild-type embryo. The territory corresponding to r5 is indicated. (B) Transverse section caudal to r5 of a Krox20^+/lacZ embryo stained for both ß-galactosidase activity (light blue) and Sox10 (purple) revealing their co-expression in the migrating neural crest. (C,D) Krox20 expression was analysed by whole-mount in situ hybridisation in Sox10 heterozygous (Sox10^+/Dom) and homozygous (Sox10^Dom/Dom) mutant embryos at 9.0 dpc (20 somites). Embryos are presented with anterior to the right. NC, neural crest; NT, neural tube.

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