Fig. 7. Lack of Nodal signaling activity leads to Fgf receptor-dependent induction of Vax gene expression. (A-J) Lateral views of brains of maternal and zygotic oep^-/- (MZoep) (A-E), and shh-injected maternal and zygotic oep^-/- (MZoep+shh) (F-J) mutant embryos analysed for expression of various genes (indicated bottom right). (K-M) atv-injected sibling embryos from smu^+/- x smu^+/- crosses showing expression of Vax genes and pax2.1 expression. (N-O) Dorsal views of Vax expression in embryos treated with the Fgf receptor inhibitor SU5402. (P-Q) Lateral views showing absence of Vax expression in atv-injected embryos treated with SU5402. Abbreviations: mb, midbrain; os, optic stalk; poa, preoptic area; r, retina; t, telencephalon.

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