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Fig. 1. Visualisation of SPUs in H253 female hemizygotes. Specimens are stained with X-Gal to reveal ß-galactosidase-positive (blue) cells. (A) The colon at 12 weeks of age, showing monoclonality of crypts. (B) The skin, epidermal wholemount viewed from exterior surface showing columns of blue cells extending through the epidermis.





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