Fig. 2. Growth of the colon in Igf2 knockout, wild-type and K:Igf2 mice. (A) Lumenal area measured at 2-4 weeks of age. (B) Semi-log plots of crypt numbers measured at 2-4 weeks of age. (C) Comparison of crypt heights measured at 2 weeks and 12 weeks of age (K:Igf2 samples indicated by K2). Each animal was sampled in triplicate and results averaged (medians indicated by horizontal bars, interquartile range by boxes and full range by vertical capped bars); n6 for each genotype tested. Kruskal-Wallis test for significance: 2-week (columns 1-3) P<0.0001; 12-week (columns 4-6) P=0.0284.

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