Fig. 7. Epidermal expansion in Igf2 knockout, wild-type and K:Igf2 mice. Mice were sampled on the day of birth (neo), at 2 weeks (2-wk) and at 12 weeks (12-wk) of age. (A) Epidermal cell number (nuclear counts). Each animal was sampled in triplicate and results were averaged (medians indicated by horizontal bars, interquartile range by boxes and full range by vertical capped bars); n6 for each genotype tested. Kruskal-Wallis test for significance: neonatal (columns 1-3) P=0.0039; 2-week (columns 4-6) P=0.0002; 12-week (columns 7-9) P=0.0015. (B) Epidermal proliferative index. Each animal was sampled in triplicate and results were averaged (medians indicated by horizontal bars, interquartile range by boxes and full range by vertical capped bars); n5 for each genotype tested. Kruskal-Wallis test for significance: neonatal (columns 1-3), P=0.2837 (not significant); 2-week (columns 4-6) P=0.0007; 12-week (columns 7-9) P=0.0693 (not significant).

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