Fig. 1. Expression of Dan and Danr induces leg to antenna transformation. (A) Cuticle preparation showing wild-type tarsal segments and claws. (B) Scanning EM of the distal leg of a Dll^Gal4 EPg3-220 fly. Note the absence of claws and presence of two aristae (arrow). Note that each claw produced an arista when Dan was expressed. In contrast to the leg, the antenna disc is not separated into A and P compartments by a lineage restriction until larval stages. The distalmost elements of A and P origin probably merge in antenna to make a single arista, which they cannot do in leg. (C,D) Distal legs from dpp^Gal4 UAS-dan and dpp^Gal4 UAS-danr animals. One claw was replaced by an arista in each case (arrows). (E) Wild-type antenna.

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