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Fig. 6. Cyclopamine treatment blocks Hh signalling in Xenopus. Whole-mount
in situ hybridisation on embryos incubated in cyclopamine solution from stage
20 onwards (B,D,F,H,J,L) or control embryos (A,C,E,G,I,K). The probes are
indicated for each panel. (C-L) Stage 41 embryos; (A,B) stage 30 embryos.
Cyclopamine treatment leads to a strong reduction of Gli1, X-Ptc-1
and X-Ptc-2 expression. Some Gli1 expression remains only in
the tailbud (arrowhead in B). Expression of both Gli2 and
Gli3 is not affected. Anterior is towards the left. Scale bar: 1.35
mm in A,B; 300 µm in C-L.
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