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Fig. 8. Overexpression of HOXD13 upregulates expression of chick EphA7, but overexpression of HOXD13(I47L) does not. Wholemounts of stage 28 chick embryos expressing HOXD13, HOXD13(I47L) or HOXD13(IQN) in the right hindlimb. Embryos were hybridised in situ with an antisense chick EphA7 probe. Chick EphA7 is expressed in the perichondrium of the digital condensations. This expression is increased in the right limbs overexpressing HOXD13 (B), but unaltered in limbs overexpressing HOXD13(I47L) (D) or HOXD13(IQN) (F). In A,C,E, the respective contralateral uninjected limbs are shown.





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