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Dallying with Dpp morphogen gradients

Dally encodes a cell-surface heparan sulfate proteoglycan that can potentiate signalling through the Decapentaplegic (Dpp) pathway during fly development. However, the exact function of Dally during wing development has remained unclear. Fujise and co-workers now shed some light on this function. On p. 1515, they report that Dally might play at least two roles in the formation of the Dpp gradient in the developing wing: by regulating the sensitivity of cells to Dpp in a cell-autonomous fashion, perhaps by acting as a co-receptor for Dpp, stabilizing the protein and so enhancing Dpp signalling; and by affecting Dpp distribution in a non-autonomous manner, possibly by sequestering Dpp – a known heparin-binding protein. These combined effects of Dally, the authors propose, determine the shape and activity of the Dpp wing gradient.

Related articles in Development:

Dally regulates Dpp morphogen gradient formation in the Drosophila wing

Momoko Fujise, Satomi Takeo, Keisuke Kamimura, Takashi Matsuo, Toshiro Aigaki, Susumu Izumi, and Hiroshi Nakato
Development 2003 130: 1515-1522. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content