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A gene expression snapshot of somatic clones

Many mouse somatic clones arrest at implantation with a pattern of developmental failure that resembles that of Oct4-deficient mouse embryos – a transcription factor-encoding gene required for inner cell mass (ICM) development. To investigate whether somatic clone embryonic development fails because of the incomplete reactivation of genes, like Oct4, that are required for the development of a pluripotent ICM, Bortvin and colleagues analysed the expression of 10 genes with an Oct4-like embryonic expression pattern, and Oct4 itself, in cloned blastocysts derived from cumulus and ES cells. Their findings, on p. 1673, show that only 62% of cumulus-derived blastocysts correctly express all eleven genes tested, whereas ES cell-derived and normal embryos express them normally, indicating that the incomplete reactivation of such genes might contribute to the embryonic failure of somatic clones.

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Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei

Alex Bortvin, Kevin Eggan, Helen Skaletsky, Hidenori Akutsu, Deborah L. Berry, Ryuzo Yanagimachi, David C. Page, and Rudolf Jaenisch
Development 2003 130: 1673-1680. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?