Fig. 2. The preoptic area prevents tangential migration towards an ectopic cortex. (A) Schematic of the slice transplantation paradigm used to analyze the migration of MGE^GFP-derived cells towards an ectopic cortex. (B) Migration of MGE^GFP-derived cells (asterisk) after 48 hours in culture, labeled with GFP. Most cells migrate towards the ipsilateral cortex, whereas very few cells migrate medially towards the ectopic cortex (arrowhead). (C) Schematic of the slice transplantation paradigm used to analyze the migration of MGE^GFP-derived cells towards an ectopic cortex in the absence of the preoptic area. (D) Migration of MGE^GFP-derived cells (asterisk) after 48 hours in culture, labeled with GFP. A large number of cells migrate towards the ectopic cortex in the absence of the preoptic area (arrowheads). eNCx, ectopic neocortex; H, hippocampus; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; NCx, neocortex; POa, preoptic area; Str, striatum. Scale bar: 300 µm.

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