Fig. 2. The subdivisions of the dorsal telencephalon are present in Fgf8neo/neo embryos. In situ hybridization on coronal sections of wild-type (A,C,E,G,I) and Fgf8neo/neo (B,D,F,H,J) E12.5 embryos performed with the indicated riboprobes. Otx2 expression in the choroids plexus (black arrows in A,B), Wnt3a expression in the cortical hem (black arrows in C,D), Lef1 (between arrowheads in E,F) and Emx2 (G,H) expression in the hippocampus primordium, and high levels of Pax6 expression in the ventral-most region of the neocortex (black arrows in I,J) do not appear modified in Fgf8neo/neo embryos. Emx2 in situ hybridization signal is slightly increased in the dorsal part of the neocortex (between arrowheads in G,H) in Fgf8neo/neo compared with wild-type embryos. The level of Pax6 expression in this same region is slightly less intense (between arrowheads in I,J). DT, dorsal thalamus; GE, ganglionic eminences; H, hippocampus; Ncx, neocortex.

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