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Fig. 3. Caudal-to-rostral gradients of expression are shifted rostrally in the
dorsal telencephalon of E12/E13 Fgf8neo/neo embryos. Whole-mount in
situ hybridization on dissected neural tubes of E12/E13 wild-type
(A,A',C,C',E,G) and Fgf8neo/neo
(B,B',D,D',F,H) embryos performed with the indicated probes.
(A-B') The high caudodorsal to low rostroventral gradient of
Emx2 expression in the dorsal telencephalon is detected in wild type
on lateral (A) and dorsal (A') viewing of the telencephalic vessicules.
Lateral (B) and dorsal views (B') of an Fgf8neo/neo embryo show
the rostral shift in the anterior limit of this gradient (compare arrowheads
in A and B). (C-D') The high caudoventral-to-low rostrodorsal gradient
of COUP-TFI expression is visible on lateral (C) and dorsal
(C') views of wild-type embryo. The anterior limit of high expression
(white arrowheads) is shifted rostrally in Fgf8neo/neo embryos. (E,F)
Dbx1 expression is normally restricted to a stripe in the caudal part
of the ventral pallium (black arrowhead in E). The anterior limit of
Dbx1 expression moves rostrally in Fgf8neo/neo embryos
(black arrowhead in F). (G,H) FgfR3 high-expression is excluded from
the rostral-most part of the telencephalon in control embryos (black arrowhead
in G). This expression domain expands into the rostral telencephalon of
Fgf8neo/neo embryos (black arrowhead in H). Tel, telencephalon.
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