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Fig. 5. Localization of Mlh1 in Brca1 mutant mice. (A,B) Scp3 and Mlh1 double immunofluorescence staining of chromosomes prepared from p53+/- control (A) and Brca1{Delta}11/{Delta}11p53+/- mutant (B) spermatocytes at the pachytene stage. Three pairs of mutant and control mice at P16, P18 and P21 were examined. There were no significant differences in Mlh1 foci formation between Brca1 mutant and control mice in (P<=0.0001). (C) Scp3 and Mlh1 double immunofluorescence localization of chromosomes prepared from Brca1{Delta}11/{Delta}11p53+/- oocytes. More than 10 mutant and control embryos at E16.5-17.5 were examined and no obvious differences were found. (D) Western blot analysis of Mlh1 and Pms2 in p53+/- (C) and Brca1{Delta}11/{Delta}11p53+/- (M) testes. Genotypes, ages and antibodies are indicated.





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