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Fig. 6. Altered localization of Rad51, but not Dmc1, in Brca1 mutant spermatocytes. Rad51 (A,B) and Dmc1 (C,D) double immunofluorescence localization of p53+/- and Brca1{Delta}11/{Delta}11 p53+/- primary spermatocytes chromosomes at the pachytene (A,B) and zygotene (C,D) stages. Three pairs of mutant and control mice at P16, P18 and P21 were examined. There were significant differences in Rad51 foci formation between Brca1 mutant and control mice (compare A with B; P<=0.0001). (E) Western blot analysis of Rad51 and Dmc1 expression in p53+/- (C) and Brca1{Delta}11/{Delta}11 p53+/- (M) testes. Genotypes, ages and antibodies are indicated.





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