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Fig. 9. Molecular events leading to defective spermatogenesis in Brca1 full-length
isoform-deficient mice. Two major functions of Brca1 during spermatogenesis
are empahasized: (1) recruiting DNA damage-repair proteins to damage sites;
and (2) regulating RNA expression of genes involved in DNA-damage repair.
Absence of the full-length isoform of Brca1 results in impaired DNA-damage
repair and leads to the termination of spermatocyte development at the
pachytene stage by p53-dependent and p53-independent apoptosis.
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